• Login
|
• Register
|
• My Account
|
• Shopping Cart
|
• Help

GPCR Products

ChemiScreen Ca²⁺-Optimized GPCR Stable Cell Lines

To meet the demands of HTS and selectivity profiling, our ChemiScreen GPCR cell lines are uniquely adapted for calcium-based functional screening. Endogenous expression of promiscuous G proteins in ChemiScreen cells funnel GPCR signaling to a common calcium readout, regardless of G protein coupling status. Calcium signaling is further enhanced by GPCR-mediated influx of extracellular calcium through endogenously expressed CRAC (calcium release activated calcium channel). The result is a superior platform for cell-based screening and profiling.

» View Product Listing

Advantages of Millipore GPCR cell lines

• High functional expression of receptors at the cell surface
• Stable cell lines for increased reliability and reproducibility
• Single and simple functional readout
• Signaling to Ca²⁺, regardless of G protein coupling status
• Identical assay conditions and data analysis for straightforward comparative studies

Proprietary pHS expression vector and ChemiScreen cell lines enhance GPCR cell surface expression

Millipore’s Stable Calcium Optimized GPCR Cell Lines simplify assay setup for screening and profiling.

Product Listing

Class	Ligand Type	GPCR Family	GPCR Target (Human unless noted)	Host Cell	ChemiScreen Ca2+-Optimized Stable Cell Line
A	non-peptide	Acetylcholine (muscarinic)	M1	Chem-1	HTS044C
A	non-peptide	Acetylcholine (muscarinic)	M2	Chem-1	HTS115C
A	non-peptide	Acetylcholine (muscarinic)	M3	Chem-1	HTS116C
A	non-peptide	Acetylcholine (muscarinic)	M4	Chem-4	HTS117C
A	non-peptide	Acetylcholine (muscarinic)	M5	Chem-1	HTS075C
A	non-peptide	Adenosine	A1	Chem-3	HTS047C
A	non-peptide	Adenosine	A2B	Chem-3	HTS051C
A	non-peptide	Adenosine	A3	Chem-3	HTS052C
A	non-peptide	Adrenergic	alpha1A	Chem-1	HTS087C
A	non-peptide	Adrenergic	alpha1B	Chem-1	HTS158C	New
A	non-peptide	Adrenergic	alpha2A	Chem-1	HTS096C
A	non-peptide	Adrenergic	alpha2B	Chem-1	HTS157C
A	non-peptide	Adrenergic	beta 1	Chem-1	HTS104C
A	non-peptide	Adrenergic	beta 2	Chem-2	HTS073C
A	non-peptide	Adrenergic	beta 3	Chem-10	HTS159C
A	non-peptide	alpha-Ketoglutarate	GPR99	Chem-1	HTS191C
A	peptide	Anaphylotoxin	C3aR	Chem-1	HTS016C
A	peptide	Anaphylotoxin	C5aR	Chem-1	HTS017C
A	peptide	Angiotensin	AT1	Chem-1	HTS064c
A	peptide	Bombesin	BB1	Chem-1	HTS123C
A	peptide	Bombesin	BB2	Chem-1	HTS084C
A	peptide	Bombesin	BB3	Chem-1	HTS160C
A	peptide	Bradykinin	B2	Chem-1	HTS041C
B	peptide	Calcitonin	CGPR1	Chem-1	HTS172C
C	non-peptide	Calcium sensor	CaS	Chem-1	HTS137C
A	non-peptide	Cannabinoid	CB1	Chem-1	HTS019C
A	non-peptide	Cannabinoid	CB2	Chem-4	HTS020C
A	peptide	Chemoattractant	ChemR23	Chem-1	HTS071C
A	peptide	Chemokine	CCR1	Chem-1	HTS005C
A	peptide	Chemokine	CCR10	Chem-1	HTS014C
A	peptide	Chemokine	CCR2B	Chem-1	HTS007C
A	peptide	Chemokine	CCR3	Chem-1	HTS008C
A	peptide	Chemokine	CCR4	Chem-5	HTS009C
A	peptide	Chemokine	CCR5, rhesus macaque	Chem-1	HTS010C
A	peptide	Chemokine	CCR6	Chem-1	HTS011C
A	peptide	Chemokine	CCR7	Chem-1	HTS012C
A	peptide	Chemokine	CCR8	Chem-1	HTS013C
A	peptide	Chemokine	CCR9	Chem-1	HTS036C
A	peptide	Chemokine	CX3CR1	Chem-4	HTS015C
A	peptide	Chemokine	CXCR1	Chem-1	HTS001C
A	peptide	Chemokine	CXCR2	Chem-1	HTS002C
A	peptide	Chemokine	CXCR3	Chem-1	HTS003C
A	peptide	Chemokine	CXCR4	Chem-1	HTS004C
A	peptide	Chemokine	XCR1 / GPR5	Chem-4	HTS053C
A	peptide	Cholecystokinin	CCK1	Chem-1	HTS184C
A	peptide	Cholecystokinin	CCK2	Chem-1	HTS083C
B	peptide	CRF Receptor	CRF1	Chem-1	HTS023C
B	peptide	CRF Receptor	CRF2	Chem-1	HTS024C
A	non-peptide	Dopamine	D1	Chem-6	HTS102C
A	non-peptide	Dopamine	D2L	Chem-7	HTS039C
A	non-peptide	Dopamine	D5	Chem-1	HTS129C
A	peptide	Endothelin	ETA	Chem-1	HTS070C
A	peptide	Endothelin	ETB	CHO	HTS046C
A	non-peptide	Free Fatty Acid	GPR40	Chem-1	HTS038C
A	non-peptide	Free Fatty Acid	GPR41	Chem-4	HTS135C
A	non-peptide	Free Fatty Acid	GPR43	Chem-1	HTS063C
C	non-peptide	GABAB	GABAB1b	Chem-1	HTS119C
A	peptide	Galanin	GAL1	Chem-1	HTS094C
A	peptide	Galanin	GAL2	Chem-1	HTS186C
B	peptide	Glucagon	GIP	Chem-9	HTS134C
B	peptide	Glucagon	GLP-1	Chem-9	HTS163C
B	peptide	Glucagon	glucagon	Chem-1	HTS112C
B	peptide	Glucagon	secretin receptor	Chem-1	HTS174C
A	peptide	Glycoprotein hormone	TSH	Chem-10	HTS133C	Coming Soon
A	peptide	GnRH	GnRH	Chem-1	HTS027C
A	non-peptide	Histamine	H1	Chem-3	HTS050C
A	non-peptide	Histamine	H2	Chem-2	HTS086C
A	non-peptide	Histamine	H3	Chem-3	HTS029C
A	peptide	KiSS1-derived peptide	KiSS1 / GPR54	Chem-1	HTS032C
A	non-peptide	Leukotriene	BLT1	Chem-1	HTS042C
A	non-peptide	Leukotriene	CysLT1	Chem-1	HTS061C
A	non-peptide	Leukotriene	CysLT2	Chem-1	HTS088C
A	non-peptide	Lysophospholipid	LPA1	Chem-1	HTS089C
A	non-peptide	Lysophospholipid	LPA3	Chem-1	HTS130C
A	non-peptide	Lysophospholipid	S1P1	Chem-4	HTS17C
A	non-peptide	Lysophospholipid	S1P2	Chem-1	HTS078C
A	non-peptide	Lysophospholipid	S1P3	Chem-1	HTS097C
A	non-peptide	Lysophospholipid	S1P4	Chem-5	HTS192c
A	non-peptide	Lysophospholipid	S1P5	Chem-5	HTS193C
A	peptide	Mas-related gene	MrgD2	Chem-1	HTS206C	New
A	peptide	Mas-related gene	MRGX2	Chem-1	HTS058C
A	peptide	Melanin-concentrating hormone	MCHR1	Chem-1	HTS025C
A	peptide	Melanin-concentrating hormone	MCHR2	Chem-1	HTS026C
A	peptide	Melanocortin	MC2	Chem-1	HTS021C
A	peptide	Melanocortin	MC4	Chem-3	HTS105C
A	peptide	Melanocortin	MC5	Chem-10	HTS155C
A	peptide	Motilin	motilin receptor, MTLR	Chem-1	HTS121C
A	peptide	Neuromedin U	NMU1	Chem-1	HTS062C
A	peptide	Neuropeptide B/W	NPBW1 / GPR7	Chem-4	HTS180C
A	peptide	Neuropeptide Y	Y2	Chem-1	HTS066C
A	peptide	Neuropeptide Y	Y4	Chem-1	HTS204C
A	peptide	Neurotensin	NTR1	Chem-1	HTS034C
A	peptide	N-formylpeptide	FPR1	Chem-1	HTS018C
A	peptide	N-formylpeptide	FPRL1	Chem-1	HTS056C
A	non-peptide	Nicotinic Acid	GPR109A	Chem-4	HTS201C
A	peptide	Opioid	Delta	Chem-1	HTS100C
A	peptide	Opioid	Kappa	Chem-1	HTS095C
A	peptide	Opioid	Mu	Chem-5	HTS101C
A	peptide	Opioid	NOP/ORL1	Chem-1	HTS040C
A	peptide	Orexin	OX1	Chem-1	HTS175C
A	peptide	Orexin	OX2	Chem-1	HTS045C
A	peptide	Oxytocin	OT	Chem-1	HTS090C
A	non-peptide	P2 / Purinergic (metabotropic)	P2Y1	1321N1	HTS049C
A	peptide	Peptide P518	GPR103/QRFP	Chem-1	HTS189C
A	non-peptide	Platelet Activating Factor	PAF	Chem-1	HTS076C
A	peptide	Prokineticin	PK1	Chem-1	HTS074C
A	peptide	Prokineticin	PK2	Chem-1	HTS182C
A	peptide	Prolactin-releasing peptide	PRP	Chem-1	HTS057C
A	non-peptide	Prostanoid	DP	Chem-1	HTS091C
A	non-peptide	Prostanoid	EP1	Chem-1	HTS099C
A	non-peptide	Prostanoid	EP2	Chem-9	HTS185C
A	non-peptide	Prostanoid	EP3	Chem-1	HTS092C
A	non-peptide	Prostanoid	EP4	Chem-1	HTS142C
A	non-peptide	Prostanoid	FP	Chem-1	HTS093C
A	non-peptide	Prostanoid	IP1	Chem-1	HTS131C
A	non-peptide	Prostanoid	TP	Chem-1	HTS081C
A	peptide	Protease-activated	PAR2	Chem-1	HTS037C
A	peptide	Protease-activated	PAR4	Chem-1	HTS162C
B	peptide	PTH receptor	PTH1	Chem-1	HTS030C
B	peptide	PTH receptor	PTH2	Chem-1	HTS173C
A	non-peptide	Serotonin	5-HT1A	Chem-3	HTS107C
A	non-peptide	Serotonin	5-HT2A	Chem-1	HTS082C
A	non-peptide	Serotonin	5-HT2B	CHO	HTS109C
A	peptide	Somatostatin	sst2	Chem-1	HTS028C	New
A	non-peptide	Serotonin	5-HT2C	Chem-1	HTS132C
A	peptide	Somatostatin	SST3	Chem-1	HTS171C
A	peptide	Somatostatin	SST4	Chem-1	HTS125C
A	peptide	Somatostatin	SST5	Chem-1	HTS139C