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Millipore Tyrosine Kinases with BioForm Technology

Enhance phosphorylation with BioForm-enabled assembly


MILLIPORE TYROSINE KINASES COUPLED WITH INNOVATIVE BIOFORM TECHNOLOGY PROVIDE A BETTER, MORE BIOLOGICALLY RELEVANT ENVIRONMENT FOR YOUR RESEARCH AND DISCOVERY EFFORTS

Tyrosine phosphorylation of and by transmembrane proteins is one of the key steps in so much of today’s research, from early stage drug screening to signal transduction and regulation of enzymatic activity. Yet studying this step can be challenging. For years, the solution has been to settle on receptor fragments commercialized for pair-wise interactions. However, much information is lost in these experiments since signaling proteins need other ‘team members’ to become fully functional. This activity typically arises from the assembly of a complex signaling team formed near the membrane surface. Analysis of a single protein interacting with a single partner loses the rich, two-dimensional information afforded by the membrane surface.

A BETTER WAY TO STUDY TRANSMEMBRANE RECEPTORS

At Millipore, we’re committed to providing you with the best tools so you can focus on what matters most: advancing your research forward. That’s why we’re proud to offer BioForm technology that enables you to assemble histidine-tagged proteins in a way that mimics the environment created by the cell membrane. This synthetic template, now bundled with select tyrosine kinases, restores the organizing features of the membrane without the difficulties of membrane preparation and reconstitution procedures.

ASSEMBLE COMPLEX PATHWAYS IN VITRO

BioForm technology’s unique protein-assembly capability leads to biologically relevant function and the flexibility to assemble complex pathways easily and effectively in vitro. With BioForm technology, you receive an enhanced, more biologically relevant environment for your research. And as life scientists ourselves, we know that when you have the tools you need to work more efficiently, the results can be life-altering.

BioForm Technology Highlights:
  • Facilitates the assembly of active signaling complexes
  • Adaptable to high throughput assay format
  • Creates biologically relevant assay condition
  • Applicable to many signaling systems

Use BioForm Technology for:
  • Early stage drug screening
  • Lead identification
  • A new avenue for target identification
  • Testing biological effects downstream of your target
  • Signal transduction research
  • Functional, in vitro assembly of multiple protein targets.


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Millipore’s Upstate Kinases with BioForm Technology
Ordering Information

Description

Catalog Number

Pack Size Description

BTK and BioForm

30-118

14-552  (10 ug) and 12-711 (100 assays)

EphB2 and BioForm

30-119

14-553  (10 ug) and 12-711 (100 assays)

IGF-1R and BioForm

30-120

14-465  (10 ug) and 12-711 (100 assays)

IR and BioForm

30-121

14-466  (10 ug) and 12-711 (100 assays)

Met and BioForm

30-122

14-526  (10 ug) and 12-711 (100 assays)

Tie2 and BioForm

30-123

14-540  (10 ug) and 12-711 (100 assays)

Lck and BioForm

30-124

14-442  (10 ug) and 12-711 (100 assays)

Fak and BioForm

30-125

14-720  (10 ug) and 12-711 (100 assays)

ErbB4 and BioForm

30-126

14-569  (10 ug) and 12-711 (100 assays)

PKCg and BioForm

30-127

14-483  (10 ug) and 12-711 (100 assays)

Axl and BioForm

30-128

14-512  (10 ug) and 12-711 (100 assays)

TrkB and BioForm

30-129

14-507  (10 ug) and 12-711 (100 assays)

TrkA and BioForm

30-130

14-571  (10 ug) and 12-711 (100 assays)

Flt1 and BioForm

30-131

14-562  (10 ug) and 12-711 (100 assays)


Ordering Information
DescriptionCatalog Number
BTK and BioForm30-118
EphB2 and BioForm30-119
IGF-1R and BioForm30-120
IR and BioForm30-121
Met and BioForm30-122
Tie2 and BioForm30-123
Lck and BioForm30-124
Fak and BioForm30-125
ErbB4 and BioForm30-126
PKCg and BioForm30-127
Axl and BioForm30-128
TrkB and BioForm30-129
TrkA and BioForm30-130
Flt1 and BioForm30-131

BioForm Reagent

Ordering Information
DescriptionCatalog Number
BioForm, 100 assays12-711
BioForm, 250 assays12-712
BioForm, 500 assays12-713