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NovaSeptum® Sterile Sampling Systems

       • Closed sampling eliminates the risk of cross contamination
       • Easy to use and handle
       • Unique and patented sampling system
       • Disposable unit
       • No cleaning and/or sterilization between samples
       • Sampling volumes of 5, 20, 50, 100, 250, and 1000 mL

The patented NovaSeptum sampling system is ideal for general fluid and cell culture sampling from aseptic and sterile processes. The NovaSeptum AV units meet the sampling demands of today’s high value biotherapeutic products with small, accurate volume sampling capability. The NovaSeptum units are ideal for obtaining larger volume sampling of up to 1000 mL. The sterile NovaSeptum sampling systems are easy to validate, handle and dispose of after each sampling. Unlike the majority of sampling methods that require an initial flushing before sampling, the NovaSeptum systems sample fluid directly from the batch without requiring an initial flush. The aseptic design and built-in safety mechanisms of the NovaSeptum sampling system eliminate the risk of cross contamination during sampling and handling. A range of NovaSeptum holders are available to connect the sampling units to a tank or pipe using the NovAseptic® connector or other standard connections.

Safe, Disposable Sampling System

The single use, disposable NovaSeptum sampling units eliminate the time and expense associated with cleaning and sterilizing traditional sampling devices. The closed design of the NovaSeptum system ensures your sample will be isolated from point of sample to analysis eliminating the risk of cross contamination.

NovaSeptum Sterile Sampling System

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The NovaSeptum single- and multi- sampling systems are available for high purity applications in sizes from 50<nbsp/>mL to 1000<nbsp/>mL. The single sampling container configurations can also be used in autoclavable applications.

The NovaSeptum systems offer a broad range of sampling solutions.

General and Cell Culture Sampling

Both the NovaSeptum general and cell culture sampling systems can be configured for high purity or autoclavable sampling applications in sizes from 5 mL to 1000 mL. For high purity applications, the NovaSeptum units are available in either single or multiple sampling container configurations. The autoclavable NovaSeptum units are available in single sampling container configurations. A wide range of holders and connectors are also available.

High Purity Units

The high purity sampling units are ideal for sterility testing, bioburden testing, endotoxin testing, chemical analysis, pH analysis, fermentation applications and applications requiring very low affinity for proteins, complex carbohydrates, or small molecules.

Autoclavable Units

The sampling units for autoclavable applications are suitable for various general sampling including biological testing, chemical analysis and when it is necessary to autoclave the vessel.

Accurate Volume Units

The unique syringe design of the NovaSeptum AV units is ideally suited for fluid and cell culture sampling in applications that require small and accurate sample volumes including high-value biotherapeutics. It also enables operators to directly dispense sample products with milliliter accuracy for testing.

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The NovaSeptum AV sampling units are available in 5 mL and 20 ml syringe sizes.

NovaSeptum Sterile Transfer System

Sample Transfer Units

Designed to aseptically move liquid from one vessel or container to another, the closed design of the NovaSeptum transfer units is ideal for applications such as pH regulation and fermentation inoculation.

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The NovaSeptum Transfer System is available as a sampling unit or tubing application.

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Flow Rates to Meet Your Sample Type

The NovaSeptum systems are available with either 1 mm or 2 mm needle. The general sampling systems include a 1 mm diameter needle in the septum, which is suitable for the majority of sampling applications. The cell culture sampling systems include a 2 mm diameter needle enabling significantly higher flow rates, which are often required in applications such as bacterial counting and sampling from bioreactors.

A Wide Range of Holders

The NovaSeptum family of holders offers a quick and easy connection to any tank or piping configuration.

       • The TC holder is designed to fit a tri-clamp connection. For an optimal aseptic solution, use with the NovAseptic connector
       • The Ingold® holder is designed to fit an Ingold connection with a standard 25 mm Ingold tube size
       • The In-line, TC holder is designed to be TC connected to a pipe for in-line sampling
       • The In-line Butt-end holder is designed to be welded to a pipe for in-line sampling

NovAseptic Connectors

Connect Easily and Securely

The NovAseptic connectors provide an ideal connection for a NovaSeptum holder with a TC flange. These flush-mounted sanitary connectors eliminate dead legs and hold-up volume improving cleanability and steamability as well as making validation easier. Contact Millipore Technical Service for ordering information.

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Specifications (return to top)

NovaSeptum Sterile Sampling Units
High PurityAutoclavableAccurate VolumeTransfer System
Maximum Sampling Pressure, bar0.50.30.50.5
Sampling Unit Volume, mL50–100050–10005 and 20250
Temperature Range, °C-20 to 50-20 to 125Single 5 mL: -20 to 123
Single 20 mL: -20 to 121
Multi: -20 to 50
Polyethylene: -20 to 50
Silicone: -50 to 95
Materials of Construction
Septum unitSeptum: Medical grade platinum-cured silicone
Body: Polyester
Cannula: ASTM 316L stainless steel
Sampling bagPolyethylene filmPolypropylene filmPolyethylene film
TubingPolyethyleneSiliconeMedical grade platinum-cured siliconePolyethylene
or silicone
Drainage bagPolyethylene filmPolyethylene film
SyringePolycarbonate, medical grade, platinum-cured silicone, medical silicone fluid
Fittings
InletSeptum unit with 1 mm or 2 mm needle
OutletTubing: 3-piece Luer, containing a male, female and an injection siteTubing: Male LuerFemale or Male LuerTubing: 3-piece Luer, containing a male, female and an injection site or a septum unit with a 1 mm or 2 mm needle
AutoclavingN/ACan be autoclaved emptyCan be autoclaved emptyN/A
USP <88> Class VIAll components in contact with sampling liquid conform with USP <88> Class VI
Integrity TestingUnits are integrity tested at regular intervals during manufacturing
AssemblyAssembled under ISO® Clean Room Class 8 conditions in a facility certified to SS-EN ISO 14644-1 standards
SterilizationThe sampling units are sterilized by beta irradiation at > 25 kGy according to ISO 11137 TIR No. 27
Bacterial EndotoxinAqueous extraction contains < 2.15 EU per device as determined using the Limulus Amebocyte Lysate (LAL) test
NovaSeptum Holders
TCIngoldIn-line, TCIn-line, butt-end
Materials of Construction
Wetted materialsStainless steel 316L,
EN 1.4435
Stainless steel 316L,
EN 1.4435
Stainless steel 316L,
EN 1.4435
Stainless steel 316L,
EN 1.4435
Magazine (blue plastic holder portion)Polyphenylene sulfide (PPS)Polyphenylene sulfide (PPS)Polyphenylene sulfide (PPS)Polyphenylene sulfide (PPS)
Autoclavable/ Steam-in-PlaceYesYesYesYes
Tube StandardsASTM® A270,
DIN 11850, Reihe 2
ASTM A270,
DIN 11850, Reihe 2
NovAseptic Connectors
Materials of Construction
Wetted materialsStainless steel 316L, EN 1.4435
Tube StandardsASTM A270, DIN 11850, Reihe 2
Connection TypeButt-end or TC


Ordering Information  (return to top)

Select up to 5 products to compare them side by side
General Fluid and Cell Culture Sampling - High Purity Sampling Units

Compare Catalogue No. Volume, mL Configuration Needle Size, mm Qty/Pk  
1711-10050 50 Single sampling 1.0 50 » Add to Cart
1711-10100 100 Single sampling 1.0 50 » Add to Cart
1711-10250 250 Single sampling 1.0 50 » Add to Cart
1711-11000 1000 Single sampling 1.0 50 » Add to Cart
1714-10100 5 x 100 Multi-sampling 1.0 5 » Add to Cart
1714-10250 5 x 250 Multi-sampling 1.0 5 » Add to Cart
2711-10050 50 Single sampling 2.0 50 » Add to Cart
2711-10100 100 Single sampling 2.0 50 » Add to Cart
2711-10250 250 Single sampling 2.0 50 » Add to Cart
2711-11000 1000 Single sampling 2.0 50 » Add to Cart
2714-10100 5 x 100 Multi-sampling 2.0 5 » Add to Cart
2714-10250 5 x 250 Multi-sampling 2.0 5 » Add to Cart
General Fluid and Cell Culture Sampling - Autoclavable Sampling Units

Compare Catalogue No. Volume, mL Configuration Needle Size, mm Qty/Pk  
1221-60050 50 Single sampling 1.0 50 » Add to Cart
1221-60100 100 Single sampling 1.0 50 » Add to Cart
1221-60250 250 Single sampling 1.0 50 » Add to Cart
1221-61000 1000 Single sampling 1.0 50 » Add to Cart
2221-60050 50 Single sampling 2.0 50 » Add to Cart
2221-60100 100 Single sampling 2.0 50 » Add to Cart
2221-60250 250 Single sampling 2.0 50 » Add to Cart
2221-61000 1000 Single sampling 2.0 50 » Add to Cart
Accurate Volume Sampling Units

Compare Catalogue No. Volume, mL Configuration Needle Size, mm Qty/Pk  
1421-50005 5 Single sampling 1.0 50 » Add to Cart
1424-50005 5 x 5 Multi-sampling 1.0 5 » Add to Cart
1421-50020 20 Single sampling 1.0 40 » Add to Cart
1424-50020 5 x 20 Multi-sampling 1.0 5 » Add to Cart
2421-50005 5 Single sampling 2.0 50 » Add to Cart
2424-50005 5 x 5 Multi-sampling 2.0 5 » Add to Cart
2421-50020 20 Single sampling 2.0 40 » Add to Cart
2424-50020 5 x 20 Multi-sampling 2.0 5 » Add to Cart
Transfer Units

Compare Catalogue No. Volume, mL Needle Size, mm Tubing Material Length, mm Fitting Outlet Qty/Pk  
3711-30250 250 2.0 Polyethylene 50 » Add to Cart
3511-10014 2.0 Polyethylene 500 3-piece Luer 50 » Add to Cart
3521-10014 2.0 Silicone 500 3-piece Luer 50 » Add to Cart
4711-40250 250 2.0 Polyethylene 50 » Add to Cart
4511-10014 2.0 Polyethylene 500 3-piece Luer 50 » Add to Cart
4521-10014 2.0 Silicone 500 3-piece Luer 50 » Add to Cart
TC Holder

Compare Catalogue No. Description Qty/Pk  
AT11/2-310 NovaSeptum Holder General Sampling, 1-port TC25 1 » Add to Cart
AT51/5-310 NovaSeptum Holder General Sampling, 5-port TC50.5 1 » Add to Cart
AT91/6-310 NovaSeptum Holder General Sampling, 9-port TC64 1 » Add to Cart
AT12/2-310 NovaSeptum Holder Cell Culture Sampling, 1-port TC25 1 » Add to Cart
AT52/5-310 NovaSeptum Holder Cell Culture Sampling, 5-port TC50.5 1 » Add to Cart
AT92/6-310 NovaSeptum Holder Cell Culture Sampling, 9-port TC64 1 » Add to Cart
Ingold Holder

Compare Catalogue No. Description Qty/Pk  
AG21/380X252-310 NovaSeptum Holder General Sampling, 2-port Ingold 1 » Add to Cart
AG22/380X252-310 NovaSeptum Holder Cell Culture Sampling, 2-port Ingold 1 » Add to Cart
In-line TC Holder

Compare Catalogue No. Description Qty/Pk  
AP11/127X94-312 NovaSeptum Holder General Sampling, 1-port, 1/2-inch tube diameter, TC25 1 » Add to Cart
AP11/191X158-312 NovaSeptum Holder General Sampling, 1-port, 3/4-inch tube diameter, TC25 1 » Add to Cart
AP11/130X100-312 NovaSeptum Holder General Sampling, 1-port, 13-mm tube diameter, TC25 1 » Add to Cart
AP11/190X160-312 NovaSeptum Holder General Sampling, 1-port, 19-mm tube diameter, TC25 1 » Add to Cart
AP12/127X94-312 NovaSeptum Holder Cell Culture Sampling, 1-port, 1/2-inch tube diameter, TC25 1 » Add to Cart
AP12/191X158-312 NovaSeptum Holder Cell Culture Sampling, 1-port, 3/4-inch tube diameter, TC25 1 » Add to Cart
AP12/130X100-312 NovaSeptum Holder Cell Culture Sampling, 1-port, 13-mm tube diameter, TC25 1 » Add to Cart
AP12/190X160-312 NovaSeptum Holder Cell Culture Sampling, 1-port, 19-mm tube diameter, TC25 1 » Add to Cart
In-line, Butt-end Holder

Compare Catalogue No. Description Qty/Pk  
AP11/127X94-311 NovaSeptum Holder General Sampling, 1-port, 1/2-inch tube diameter, butt 1 » Add to Cart
AP11/191X158-311 NovaSeptum Holder General Sampling, 1-port, 3/4-inch tube diameter, butt 1 » Add to Cart
AP11/130X100-311 NovaSeptum Holder General Sampling, 1-port, 13-mm tube diameter, butt 1 » Add to Cart
AP11/190X160-311 NovaSeptum Holder General Sampling, 1-port, 19-mm tube diameter, butt 1 » Add to Cart
AP12/127X94-311 NovaSeptum Holder Cell Culture Sampling, 1-port, 1/2-inch tube diameter, butt 1 » Add to Cart
AP12/191X158-311 NovaSeptum Holder Cell Culture Sampling, 1-port, 3/4-inch tube diameter, butt 1 » Add to Cart
AP12/130X100-311 NovaSeptum Holder Cell Culture Sampling, 1-port, 13-mm tube diameter, butt 1 » Add to Cart
AP12/190X160-311 NovaSeptum Holder Cell Culture Sampling, 1-port, 19-mm tube diameter, butt 1 » Add to Cart
Fully Adjustable Bag Racks

Compare Catalogue No. Configuration Applicable Device  
A001 Single sampling 1-port Holder In-line » Add to Cart
A002 Single sampling 1-port Holder TC25/NAC18 » Add to Cart
A003 Single sampling 5-port Holder TC50.5 » Add to Cart
A004 Single sampling 9-port Holder TC64 » Add to Cart
A005 Single sampling Ingold Holder » Add to Cart
A006 Multi-sampling 1-port Holder In-line » Add to Cart
A007 Multi-sampling 1-port Holder TC25/NAC18 » Add to Cart
A008 Multi-sampling 5-port Holder TC50.5 » Add to Cart
A009 Multi-sampling 9-port Holder TC 64 » Add to Cart
A010 Multi-sampling Ingold Holder » Add to Cart
Accessories

Compare Catalogue No. Description Qty/Pk  
A100 NovaSeptum Crimping tool 1 » Add to Cart
A103 NovaSeptum Manual Crimping Tool Spare Part Kit 1 » Add to Cart
A201 NovaSeptum Port Plug, General application 100 » Add to Cart
A202 NovaSeptum Port Plug, Cell Culture application 100 » Add to Cart