Anti-HuC
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| R, H | WB | Rabbit | Affinity Purified | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: Q14576 # May be involved in neuronal differentiation and maintenance.
SIZE: 367 amino acids; 39547 Da
TISSUE SPECIFICITY: Brain specific.
SIMILARITY: SwissProt: Q14576 ## Belongs to the RRM elav family. & Contains 3 RRM (RNA recognition motif) domains.
SIZE: 367 amino acids; 39547 Da
TISSUE SPECIFICITY: Brain specific.
SIMILARITY: SwissProt: Q14576 ## Belongs to the RRM elav family. & Contains 3 RRM (RNA recognition motif) domains.
Entrez Gene Number:
Entrez Gene Summary
A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms
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Description:
Anti-HuC
Background Information:
Hu proteins are mammalian embryonic lethal abnormal visual system (ELAV)-like neuronal RNA-binding proteins that contain three RNA recognition motifs. RNA binding protein HuC promotes neuronal development in both the central and the peripheral nervous systems. HuC antibodies are are also used as markers for developing neurons.
Specificity:
HuC. By Western blot the antibody reacts with a band at ~ 39 kDa on adult rat brain lysate and rat spinal cord lysate. An additional band at ~ 25 kDa may be seen depending on sample and antibody concentration used.
Key Applications:
Western Blotting
Species Reactivity:
- Rat
- Human
Immunogen:
Synthetic peptide near the N-terminus human/rat/mouse HuC.
Epitope:
N-Terminus
Molecular Weight:
39.5 kDa
Control:
Tested on adult rat brain lysate
Presentation:
Purified Antibody in PBS with 0.1% NaN3
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
Gene Symbol:
- ELAVL3
- PLE21
- HUCL
- MGC20653
- HUC
- HuC
- DKFZp547J036
Antibody Category:
Neuroscience
Antibody Sub-Category:
Developmental Neuroscience
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Purification Method:
Immuno Affinity Purified
Format:
Affinity Purified
Antibody Type:
Polyclonal Antibody
Host:
Rabbit