cAMP
Description:
cAMP
Trade Name:
Upstate (Millipore)
Key Applications:
Kinase Assay
Application Notes:
Used to activate PKA in vitro
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Descriptive Text:
Cyclic AMP (cAMP, adenosine 3´, 5´-cyclic monophosphate) is a nucleotide which acts as a key second messenger in multiple signal transduction pathways. cAMP regulates many cellular functions, such as metabolism, cell growth and differentiation, gene transcription, ion transport and ion channel function. It is synthesized from ATP by the action of adenylate cyclase, and is inactivated by hydrolysis to 5´-AMP by the actions of phosphodiesterases. cAMP is the downstream mediator of G proteins which activate adenylate cyclase upon ligand binding. Many different drugs, neurotransmitters and hormones exert their cellular effects by modulating adenylate cyclase activity and thus raising or lowering intracellular cAMP concentrations.
Reagent Type:
Buffers
Presentation:
20mM MOPS, 25mM β-glycerol phosphate, 5mM EGTA, 1mM sodium orthovanadate, and 1mM DTT
Protein or Enzyme Type:
Tools for Enzyme Studies
Storage Conditions:
1 year at -20°C