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ELISA Analysis: Sensitivity at 1:12,800 dilution on cGMP-Ova at 2µg/mL plate with very low cross-reactivity with cAMP on cAMP-Ova coated plates at 2µ ...
Anti-cGMP (cyclic GMP)
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| A | ELISA, RIA, IH | Rabbit | Serum | Polyclonal Antibody |
UniProt Number:
UniProt Summary
SIZE: 686 amino acids; 77804 Da
SUBUNIT: Antiparallel homodimer. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with MRVI1.
DOMAIN:SwissProt: P14619
SIMILARITY: SwissProt: P14619 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 cyclic nuc ... see more »
SUBUNIT: Antiparallel homodimer. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with MRVI1.
DOMAIN:SwissProt: P14619
SIMILARITY: SwissProt: P14619 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 cyclic nuc ... see more »
Entrez Gene Number:
Description:
Anti-cGMP (cyclic GMP)
Alternate Names:
Guanosine 3', 5'-cyclic monophosphate
Specificity:
Recognizes cGMP. Very little cross reactivity to cAMP based on ELISA.
Key Applications:
- ELISA
- Radioimmunoassay
- Immunohistochemistry
Species Reactivity:
All
Isotype:
IgG
Immunogen:
2 Monosuccinyl cyclic GMP conjugated to KLH
Storage Conditions:
2 years at -20°C from date of shipment
Gene Symbol:
- PRKG1
- cGKI-beta
- FLJ36117
- PRKG1B
- PGK
- cGKI-BETA
- PRKGR1A
- cGKI-alpha
- PRKGR1B
- cGKI
- MGC71944
- DKFZp686K042
- OTTHUMP00000061216
- CGKI
Quality Assurance:
Routinely evaluated by ELISA
Antibody Category:
Cell Signaling
Antibody Sub-Category:
GPCR, cAMP/cGMP & Calcium Signaling
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Descriptive Text:
Cyclic GMP (cGMP, Guanosine 3’, 5’-cyclic monophosphate) is a nucleotide which acts as a key second messenger in multiple signal transduction pathways. cGMP is synthesized from guanosine triphosphate (GTP) by the action of guanylate cyclase, degraded by cyclic nucleotide phosphodiesterases, which hydrolyze cGMP into 5’-GMP. Levels of cGMP are increased by the action of certain hormones, such as acetylcholine, insulin and oxytocin, as well as by chemicals such as serotonin and histamine. cGMP can also be elevated by agents which stimulate guanylate cyclase, such as nitroprusside, nitroglycerin, sodium nitrate and nitric oxide. cGMP has become an important target for drug discovery because it regulates many cellular functions, including ion channel conductance, glycogenolysis and cellular apoptosis. Significantly, it also relaxes smooth muscle tissues. In blood vessels, relaxation of vascular smooth muscles leads to vasodilation and increased blood flow.
Trade Name:
Upstate (Millipore)
Purification Method:
serum
Format:
Serum
Antibody Type:
Polyclonal Antibody
Host:
Rabbit